Journal of Pharmaceutical Research on Advanced Chemistry

(for innovative research)


Drug discovery will receive a £103 million boost at the UK’s new national life sciences institute the Rosalind Franklin Institute. Robotics, synthesis and biophysics will be brought together in a high-throughput facility that aims to make drug discovery up to 10 times more productive. A fully automated workflow will make drugs for clinical testing within weeks rather that months.

The US Food and Drug Administration (FDA) has approved a new system for generating the diagnostic radioisotope technetium-99m that it hopes will address shortages. The RadioGenix system developed by Beloit, Wisconsin-headquartered company NorthStar Medical Radioisotopesworks by separating technetium-99m from its radioactive precursor molybdenum-99, as it decays into technetium-99m. The imaging agent emits gamma radiation that is used to make images of organs or bones, for example in SPECT imaging. It is used on tens of thousands of patients in the US every year for the diagnosis of various diseases including cancer and heart disease.

Complexes of Ca, Sr and Ba adopt a transition metal-like 18-electron configuration, rather than the octet more usually found in main group compoundsThe heavier group 2 elements appear to involve their empty d-orbitals more in bonding than previously suspected. Calcium, strontium and barium can all form 18-electron octacarbonyl complexes with carbon monoxide, more akin to those formed by transition metals than other main group elements. The new results challenge previous notions of coordination chemistry and expand the limits of a widely accepted rule.

The large percentage of deaths from cardiovascular disease has prompted an international group of experts from Germany, England, and the USA to analyze the negative effects of air pollution on vascular function in a review article. Key research questions focused on components of air pollution (particulate matter, ozone, nitrogen dioxide, carbon monoxide, and sulfur dioxide) that are particularly damaging to the cardiovascular system and mechanisms that damage the vessels.

In a nanoparticle form, the normally very stable, inert, noble metal actually gets dismantled by a microbe found on a Brazilian aquatic weed. While the findings don't provide dire warnings about any unknown toxic effects of gold, they do provide a warning to researchers on how it is used in certain experiments.

The study was published August 13 in the journal Nature Nanotechnology.